Significance and Security

 The eyes of the LORD are toward the righteous, and his ears toward their cry. The face of the LORD is against those who do evil, to cut off the memory of them from the earth. When the righteous cry for help, the LORD hears and delivers them out of all their troubles. The LORD is near to the brokenhearted and saves the crushed in spirit. Many are the afflictions of the righteous, but the LORD delivers him out of them all.

Psalm 34:15-19 (ESV)
 
Those who trust in God will never be ashamed. They may and should be disappointed in this life; they may be rejected, hated, despised, and even persecuted, but never ashamed.
 
Those who are ashamed of being Christians or Christ followers do not know God. If you spend time getting to know God, it will be well spent, for at some point in the process, the world and the universe make sense, and your part within both becomes relevant.
 
Significance and security come from knowing God, pointing to Him, and consistently doing that daily and in every circumstance.